Modified Lipoproteins in the Pathogenesis of Atherosclerosis (Medical Intelligence Unit) - Tapa dura

A number of epidemiological and experimental animal studies have shown that some kind of an oxidative process is involved in atherosclerosis. Recent evidence suggests that the oxidation of low-density lipoprotein (LDL) may render it more atherogenic. The oxidized LDL exhibits multiple pro-atherogenic properties. This text discusses the mechanisms of the formation of oxidized LDL and its atherogenic effects on cells of the arterial. The potential role of antioxididants in preventing heart disease is also critically addressed.